Optimizing the efficiency of assisted reproduction procedures in the common marmoset (Callithrix jacchus) improved IVF outcomes

In common marmosets (Callithrix jacchus), progesterone level <10 ng/mL at IVF cycle start and shorter stimulation (7–14 days) are linked to higher cleavage-stage embryo development.

• Why it matters: Marmoset IVF is less efficient than in other primates, limiting genetic manipulation; identifying hormonal and stimulation factors could improve embryology outcomes.
• What they did: Using longitudinal data collected over 2 years, the study analyzed associations among age, number of cycles, and progesterone levels, including serum progesterone 24 hours after Cloprostenol sodium (Estrumate) and stimulation duration with fertilization and cleavage outcomes.
• The result: Higher progesterone at cycle start was negatively correlated with fertilized eggs reaching cleavage, while shorter stimulation (7–14 days) with a GnRH antagonist correlated with increased cleavage percentages and optimization yielded high implantation after embryo transfer for fresh or cryopreserved embryos.

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