Residual Symptoms and Quality of Life in Female Patients with Hypothyroidism and Cardiovascular Disease

In 82 women with hypothyroidism and cardiovascular disease on treatment, higher TSH within the euthyroid range was not significantly linked to worse ThyPRO-39 symptom burden.

• Why it matters: Biochemical normalization of TSH does not always match symptom relief or health-related quality of life, especially when comorbidities may contribute to persistent symptoms.
• What they did: After excluding 14 of 96 women whose study-visit TSH fell outside 0.35–4.94 μIU/mL, the study tested associations between TSH quartiles and ThyPRO-39 using multivariable regression and ordered trend testing.
• The result: Major depressive disorder (β=16.93, 95% CI 8.22–25.65; p<.001) and hypertension (β=12.45, 95% CI 2.24–22.66; p=.018) were independently associated with higher ThyPRO-39 scores, suggesting comorbidities may better explain residual symptoms than modest TSH variation.

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