Associations Between Cannabis Use and Sleep Outcomes in a Sample of Pregnant Women

Cannabis use during pregnancy is linked to heightened insomnia symptoms specifically in the third trimester, compared with no cannabis use, in a cohort of 298 users and 143 nonusers.

• Why it matters: Sleep difficulties and cannabis use during pregnancy are both common and tied to adverse outcomes, yet trimester-specific sleep associations and motives for use remain unclear.
• What they did: In a cohort study, cannabis use was assessed each trimester by self-report and urine drug screening, with cotinine included as a nicotine covariate; insomnia, sleepiness, sleep quality, and restless legs were measured each trimester.
• The result: A CUP status-by-trimester interaction was observed for insomnia (F(2,737.81)=4.98, PFDR=0.03), and third-trimester use predicted higher insomnia; first-trimester sleep-motive users reported worse insomnia (F(1,223)=13.09, PFDR=0.001) and poorer sleep quality (F(1,219)=7.86, PFDR=0.01).

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