Circadian multimodal physiological, ocular and behavioural data from a 40-hour forced-desynchrony protocol

A multimodal 40-hour forced-desynchrony dataset from twelve healthy adults captures circadian dynamics across ocular, physiological, and behavioral measures within a 3 h 45 min ultradian cycle.

• Why it matters: Circadian and homeostatic processes are hard to separate in normal schedules, limiting reuse for cross-domain studies of time-of-day effects.
• What they did: Twelve adults (19–30 years, 50% female) followed a 2 h 30 min wake in dim light and 1 h 15 min sleep in darkness (2:1 wake:sleep) protocol, with repeated visual psychophysics, pupillometry, OCT, intraocular pressure, vigilance, hormones, questionnaires, plus continuous actigraphy, ECG, temperature, blood pressure, and interstitial glucose.
• The result: The dataset, including pilot data and two excluded candidates’ screenings plus supplementary evening sessions for circadian phase via salivary melatonin and dim-light melatonin onset, enables reuse to study circadian dynamics across multiple domains.

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