Role of the gut microbiota in the remodelling of the jejunal, colonic, hepatic and blood proteomes in a mouse model of Anorexia Nervosa

Activity-based anorexia in male mice triggers extensive proteome remodeling across jejunum, colon, liver, and blood, with over 250 proteins altered versus controls.

• Why it matters: Gut dysbiosis is linked to anorexia nervosa, but its physiological consequences across multiple organs are not well defined.
• What they did: Using the murine ABA model, the team compared intact versus gut-microbiota-depleted mice and antibiotic-treated groups, identifying 75 gut-microbiota-dependent proteins and a significant rise in circulating proteasome in ABA blood.
• The result: Gut-microbiota-dependent regulation was identified for a subset of targets, while most changes appeared driven by starvation and activity; ORM2 decreased in ABA mice and also in patients with AN.

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