A Comparison and Validation of BIDS Apps for Preprocessing of UCB-J PET data

BIDS apps PETPrep and PICNIC yield highly consistent [11C]UCB-J total distribution volume (VT) across 9 brain regions, with intraclass correlation coefficients from 0.94 to >0.99 in 14 placebo subjects.

• Why it matters: PET preprocessing varies and can include manual steps that reduce comparability and reproducibility across analyses, motivating standardized, automated BIDS-based pipelines.
• What they did: In a randomized controlled trial, 14 subjects received placebo and underwent two [11C]UCB-J PET scans; VT was computed with a 1-tissue compartment model (kinfitr), and arterial inputs were processed with Bloodstream.
• The result: Signed percentage differences showed region-dependent bias between tools (0.1%–10.2%), test-retest metrics were similar, and negative test-retest bias in VT of unknown origin was observed.

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