Foreign Body Responses Adapt to Systemic Immunosuppression to Maintain Local Immune Homeostasis Through Decorin-Associated Signaling

Porous polycaprolactone scaffold implants in endotoxin-tolerant and tumor-bearing mice maintain locally immune-active environments with elevated CXCL1 despite systemic immunosuppression.

• Why it matters: Mechanistic foreign body response studies often use healthy hosts, leaving uncertainty about how implanted biomaterial immunity is regulated under systemic immune dysfunction.
• What they did: Mice with endotoxin tolerance or aggressive breast tumors received porous PCL scaffolds; local immune-cell profiles and mediators were measured, and decorin’s role was tested using recombinant decorin with TLR2/4-associated signaling and migration assays.
• The result: CXCL1 preferentially recruited neutrophils and enriched pro-inflammatory phenotypes in splenocytes from both immunosuppressed groups, while decorin was enriched in scaffolds but reduced in major organs, promoting CXCL1 via TLR2/4-linked myeloid activation.

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