Immuno-Proteomic Age of Cardiovascular Etiology (iPACE) Signature Predicts Cardiovascular Risk in Elderly Patients

A 30-protein serum immune proteomics iPACE signature of age in older adults is linked to HFpEF and ASCVD risk and mortality.

• Why it matters: Age strongly predicts cardiovascular disease, but immune mechanisms shaping HFpEF and atherosclerotic CVD risk are not well captured by standard clinical measures.
• What they did: Using two independent cohorts of older adults, the study built an iPACE model from serum immune proteomics and tested its correlations with HFpEF and ASCVD outcomes.
• The result: The iPACE signature identifies aging-related immune proteins associated with ASCVD and HFpEF resilience versus susceptibility, supporting prognostic, diagnostic, and potential therapeutic targeting.

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