Peripheral Exercise Transcriptomes Do Not Converge on Glutamatergic or Neuroinflammatory Signatures: A Cross-Platform Meta-Analysis

Peripheral exercise transcriptomes across skeletal muscle, whole blood, and circulating neutrophils show no significant glutamatergic or neuroinflammatory convergence, with zero genes shared across all three studies.

• Why it matters: It is unclear whether LPFC glutamatergic dysregulation linked to overtraining fatigue is mirrored in peripheral gene expression, leaving a biomarker gap.
• What they did: The authors meta-analyzed three GEO datasets using limma across four exercise groups, applying nominal p < 0.05 and |log2 fold change| > 0.5 to call DEGs.
• The result: Enrichment of the DEG union highlighted ribosome and protein folding/translation and T cell activation, while glutamatergic or neuroinflammatory pathways did not reach significance and muscle–blood concordance was absent (r = 0).

AI summary of the abstract · may contain errors · not medical advice · read the paper.