EigenBrain maps cortical molecular architecture from functional, geometric, and structural eigenmodes

Functional MRI-derived eigenmodes can selectively approximate eight receptor and transporter maps (serotonin, dopamine, histamine, cholinergic, opioid), while structural and geometric eigenmodes cannot.

• Why it matters: It is unclear whether the MRI modality used for eigenmodes determines which molecular topographies can be reconstructed, limiting mechanistic interpretation in large cohorts without molecular imaging.
• What they did: A spatial reconstruction framework tested 23 molecular systems across neurotransmitter, metabolic, and pathological markers, comparing reconstructions from functional versus structural versus geometric MRI eigenmodes.
• The result: Functional organization encodes a specific subset of neuromodulatory topographies, enabling eigenmode decompositions to detect autism cross-sectional differences and schizophrenia longitudinal changes in cohorts lacking molecular imaging.

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