Stress-induced Metabolic Remodeling of Adipose and Brain Tissue Revealed by Positron Emission Tomography

Acute immobilization and surgery in mice activate brown adipose tissue as a stress response, independently of hypothermia, making it a highly stress-sensitive metabolic hub.

• Why it matters: Stress triggers physiological adaptation, but the metabolic programs across organs during stress are not well defined, limiting mechanistic understanding and tracking of stress biology.
• What they did: The study used total-body positron emission tomography (PET) combined with multi-OMICS and endocrine profiling across multiple murine stress models to map systemic metabolic remodeling.
• The result: It revealed stress-specific hypo- and hypermetabolic signatures across brain regions and linked brain–adipose networks across stress groups, enabling minimally invasive PET tracking of metabolic stress responses in mice.

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