The abstract is read at the publisher; the summary is JClub's.
Mitotic epigenetic age is higher in tumor than matched normal tissue across all 13 adult solid cancers (506 pairs), robust to purity and cell composition.
- Why it matters: Tumor epigenetic clocks may track different biology, but it was unclear how replicative versus chronological measures relate to within-tumor methylation heterogeneity and genome instability.
- What they did: The study compared four mitotic clocks and the Horvath pan-tissue clock in matched adult tumor–normal pairs and in 1,731 pediatric tumors, testing links to grade, stage, genome instability, and methylation heterogeneity.
- The result: Mitotic clock advance tracks tumor grade, stage, and genome instability (with stemTOC showing a small proliferation component), while Horvath clock is cancer-type specific; in children 98.1% of tumors show Horvath age above chronological age.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.