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From junk to deleterious: Natural subtelomeric repeat amplifications impact fitness and cellular phenotypes in yeast
bioRxiv · · Preprint · Open access
Henault, Fogg + 1 more
Abstract ↗AI summary
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Massive Y' subtelomeric tandem repeat amplifications in budding yeast are linked to a significant fitness cost, alongside extreme structural diversity among near-isogenic strains.
- Why it matters: Structural variants can emerge from repetitive DNA that is thought to evolve neutrally, but how such transitions become evolutionarily meaningful is unclear.
- What they did: Using budding yeast population genomics, the study characterizes multiple massive Y' element amplifications and tests their effects on fitness and cellular phenotypes, including transcriptome rewiring and replication stress sensitivity.
- The result: Y' amplifications are associated with heightened DNA replication stress sensitivity and DNA damage response activation, supporting a model where subtelomeric amplification pushes Y' beyond effective neutrality into deleterious impact.
The findingWhy it mattersWhat they didThe result
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