DNA-MGC+: A versatile codec for reliable and resource-efficient data storage on synthetic DNA

DNA-MGC+ enables reliable DNA data decoding up to 24% error rate for a 15-KB file in in silico tests, improving reliability and efficiency under explicit constraints.

• Why it matters: Noisy DNA synthesis, amplification, and sequencing create insertion, deletion, substitution errors and dropouts, making dependable retrieval difficult and resource-intensive.
• What they did: The team evaluated DNA-MGC+ across in silico and in vitro settings, comparing it with representative codecs while measuring sequencing depth, read cost, decoding time, storage density, and error-correction performance.
• The result: In silico results support reliable decoding at 24% error for 15-KB and up to 200 MB at 5% error; in vitro, a 24-KB file with electrochemical synthesis achieved minimum sequencing depth below 3x and read cost below 3.5 nts/bit on both Illumina and Nanopore.

AI summary of the abstract · may contain errors · not medical advice · read the paper.