Spliformer-V2 enables multi-tissue prediction and interpretation of splice-altering genetic variants

bioRxiv · 11 Aug 2026 · Preprint · Open access

Tang, Shao + 15 more

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Kinase-phosphatase cycles drive self-sustained oscillations of protein condensates
bioRxiv · 12 Nov 2026 · Preprint
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ATP-driven kinase–phosphatase cycling drives self-sustained oscillations in TDP-43 low complexity domain condensates, with condensates repeatedly appearing and disappearing under constant chemical driving.
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https://jclub.com.au/a/10.64898/2026.10.27.762139
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Base composition reflects RNA polymerase II displacement.
Genome Research · 11 Nov 2026 · Journal Article
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Genes show two conserved base-composition patterns near RNA polymerase II displacement, with one class marked by an additional GC-rich region around the site.
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https://jclub.com.au/a/42907152
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Aberrant splicing prediction during human organ development
bioRxiv · 11 Nov 2026 · Preprint
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AbSplice extended with developmental splicing dynamics predicts >18,000 brain variants with splicing-disruptive effects confined to early development, improving accuracy across embryonic to adult tissues.
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https://jclub.com.au/a/10.1101/2025.07.16.665183
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Spliformer-V2 enables multi-tissue prediction and interpretation of splice-altering genetic variants

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Kinase-phosphatase cycles drive self-sustained oscillations of protein condensates

Base composition reflects RNA polymerase II displacement.

Aberrant splicing prediction during human organ development

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