High-risk rhabdomyosarcomas share a common neural-like cell state, regardless of FOXO1 fusion status, revealing a convergent transcriptional phenotype in lethal cases.
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FOXO transcription factor regulation
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Loss of Lsp2 reduces TOP mRNA translation via 4E-BP, extending Drosophila lifespan independently of rapamycin, highlighting a new longevity pathway.
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Hepatocytes support pancreatic cancer liver metastasis by producing serine through a CXCL5-CXCR2-driven pathway, promoting tumor growth in the liver.
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Chronic exposure to cigarette and waterpipe smoke extracts causes telomere shortening and increases telomerase activity, promoting cancer progression in lung, colon, and breast cancer cells.
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Stage-specific degradation of cyclin D3 prevents myeloproliferative neoplasms by regulating myelopoiesis, with sustained levels causing MPN development in mice.
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