The CYB5R3 T117S variant reduces riociguat efficacy by impairing nitric oxide signaling in sickle cell disease patients.
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Persistent hyperhomocysteinemia in an adolescent with celiac disease and homozygous MTHFR c.665C>T polymorphism was significantly reduced by targeted vitamin therapy.
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Chlorophyll-c molecules in photosynthetic complexes predominantly coordinate from the β-side, contrasting with the α-ligation preference of other (B)Chls, with 24 of 42 molecules showing this trait.
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