Single-cell RNA sequencing reveals oncogenic transcriptional programs and immune escape mechanisms in over 2 million cells from CTCL patients, highlighting therapeutic vulnerabilities.
Cutaneous lymphoproliferative disorders research
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CD19 CAR T cell therapy demonstrated acceptable safety and significant clinical improvements in six patients with treatment-refractory seropositive rheumatoid arthritis, with a median 34% DAS28-CRP reduction.
Anti-BCMA/GPRC5D bispecific CAR T cells achieved a 97% overall response rate in patients with relapsed or refractory multiple myeloma with extraosseous extramedullary disease.
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Single-day nonactivated IL-18-armed CAR T cells achieve durable, stemlike states with enhanced persistence and antitumor activity across multiple cancer models.
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