Chronic pancreatitis involves progressive inflammation and fibrosis, with early-stage mechanisms and biomarkers remaining poorly understood, hindering disease-modifying treatments.
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IgG4-Related and Inflammatory Diseases
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Obexelimab significantly delays disease flares and reduces glucocorticoid use in IgG4-related disease, with a hazard ratio of 0.44 and fewer flares compared to placebo.
- 2 cites
Patient-derived organoids reveal widespread CFTR dysfunction in half of chronic pancreatitis cases, including those with wild-type CFTR, and respond to CFTR modulators.
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