Erythropoietin and Anemia Treatment
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KDIGO 2026 guidelines recommend intravenous iron over oral iron and ESA as the first-line treatment for anemia in CKD, with a target hemoglobin below 11.5 g/dL.
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Preoperative anemia affects up to 50% of cardiac surgery patients and significantly increases morbidity and mortality risks.
RAAS inhibitors significantly decrease hemoglobin levels in sickle cell disease patients and mouse models, worsening anemia by approximately 0.5 g/dL.
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