Blood Coagulation and Thrombosis Mechanisms

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Chen L, Hu L, Liu X, et al. Single-cell profiling of ANKRD26 thrombocytopenia reveals progenitor expansion and polyploid apoptosis via JUNB-p21. Blood. 2026;147(17):1984-1998.
Blood · 22 Oct 2026 · Journal Article
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Role for Factor XIa Inhibitors after an Acute Coronary Syndrome Event.
New England Journal of Medicine · 22 Oct 2026 · Editorial
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Reframing APS thrombogenesis: a new PF4-driven mechanism.
Blood · 22 Oct 2026 · Editorial
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Anticoagulation with the mechanistically distinct FXI/FXIa antibodies amrecibart (REGN9933A2) and cenvacibart (REGN7508Cat).
Blood · 8 Oct 2026 · Clinical Trial, Phase I
FXI-targeting monoclonal antibodies amrecibart and cenvacibart inhibit intrinsic pathway-triggered coagulation without affecting extrinsic pathway in humans and primates.
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Factor IX Padua AAV gene therapy in adolescents with hemophilia B: a phase 1 trial.
Nature Medicine · 1 Oct 2026 · Clinical Trial, Phase I
AAV gene therapy BBM-H901 is safe and reduces bleeding episodes in 11 adolescents with hemophilia B, with FIX activity reaching an average of 41.8 IU/dl at 52 weeks.
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One-stage assay factor VIII activity reflects AAV-derived factor VIII-enhanced thrombin activation and predicts phenotype.
Blood · 1 Oct 2026 · Journal Article
One-stage assay FVIII activity accurately reflects AAV-FVIII-SQ function and better predicts bleeding outcomes in hemophilia A gene therapy than chromogenic assays.
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Extravascular coagulation stabilizes pro-fibrotic stromal states via tumor-intrinsic PAR1 signaling in pancreatic ductal adenocarcinoma
bioRxiv · 3 Sept 2026 · Preprint
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Phase 3 Trial of Oral Infigratinib in Children with Achondroplasia.
New England Journal of Medicine · 3 Sept 2026 · Randomized Controlled Trial
In children with achondroplasia, 52 weeks of oral infigratinib increased annualized height velocity by 1.74 cm compared to placebo, showing significant growth benefits.
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Prognosis of Recurrent Venous Thromboembolism During Extended Apixaban Therapy for Cancer-Associated Thrombosis: Insights From the API-CAT Randomized Trial.
Circulation · 1 Sept 2026 · Letter
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Recurrent Venous Thromboembolism in Cancer: A Foreboding Event.
Circulation · 1 Sept 2026 · Editorial
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Catheter-Directed Thrombolysis in Intermediate-High-Risk Pulmonary Embolism.
New England Journal of Medicine · 31 Aug 2026 · Journal Article
Catheter-directed thrombolysis reduces the risk of death, recurrence, or cardiorespiratory collapse within 7 days in patients with intermediate-high-risk pulmonary embolism, with only minimal bleeding risks.
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Inhibiting thromboinflammation via interleukin-4 binding to platelet glycoprotein VI and suppression of thrombosis.
Blood · 27 Aug 2026 · Journal Article
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