Microbial systems have been engineered to significantly enhance the biosynthesis of SAM and its derivatives, enabling sustainable production of high-value compounds.
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Folate and B Vitamins Research
Moving in bioRxiv, Journal of Experimental Botany, Biotechnology advances, Cell Metabolism, Frontiers in Genetics, Journal of hepatology, Nature Cancer, Plant Physiology and Biochemistry.
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Elevating methionine levels in plants alters development, stress responses, and epigenetic regulation, but is constrained by the plant’s metabolic control mechanisms.
- Open access
MTA overaccumulation in Arabidopsis reproductive tissues reduces sulfur metabolites and alters methylation, impairing development and fertility.
- Open access
Liver-directed lentiviral gene therapy achieves long-lasting metabolic correction in MMA mice, with over 80% hepatocyte transduction and therapeutic effects lasting more than a year.
- Open access
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The GmMYB093-GmCYP90A1-BR module enhances soybean adaptation to iron deficiency by regulating key physiological and molecular responses.
Maternal vitamin B12 deprivation increases offspring obesity by reducing early colonization of Bifidobacterium pseudolongum during lactation.
Persistent hyperhomocysteinemia in an adolescent with celiac disease and homozygous MTHFR c.665C>T polymorphism was significantly reduced by targeted vitamin therapy.
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Loss of MTRR-1 in Caenorhabditis elegans disrupts heterochromatin and mitochondrial homeostasis independently of methionine synthesis, with a 50% reduction in heterochromatic histone methylation.
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