The abstract is read at the publisher; the summary is JClub's.
Cold-induced brown adipose tissue thermogenesis is maintained across dietary contexts, but glucose uptake is diet-responsive and is independent of GLUT1, with GLUT4 loss blocking uptake and thermogenesis only under low dietary lipids.
- Why it matters: It remains unclear in vivo when and how BAT relies on glucose during cold exposure, and whether proposed glucose transporters are required under different nutrient conditions.
- What they did: The study tested cold-activated BAT in mice and assessed glucose uptake and thermogenesis across dietary contexts, using transporter perturbations showing cold-induced uptake is not GLUT1-dependent and that inducible GLUT4 loss abolishes uptake and impairs thermogenesis under low-lipid cold stress.
- The result: Brown adipocytes can sustain ATP without glycolysis during substantial mitochondrial uncoupling when alternative nutrients are available, implying BAT thermogenesis is supported by metabolic flexibility in vivo.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.