The abstract is read at the publisher; the summary is JClub's.
Near-infrared–driven yolk-shell nanomotor mPDA-C@M penetrates deep into avascular cartilage and improves osteoarthritic outcomes in rat and rabbit models.
- Why it matters: Dense cartilage extracellular matrix limits delivery to deep inflammatory lesions, undermining efforts to restore immune microenvironment homeostasis and slow osteoarthritis progression.
- What they did: The authors built an asymmetric yolk-shell nanomotor combining cerium(IV) oxide catalytic propulsion with mPDA-enabled thermophoretic motion, using near-infrared irradiation to reinforce directional transport.
- The result: In rat and rabbit models, the dual approach scavenges reactive oxygen species and applies mild photothermal stimulation, up-regulating HSP70 and suppressing nuclear factor κB/mitogen-activated protein kinase signaling to reduce degeneration and promote matrix synthesis and joint repair.
The findingWhy it mattersWhat they didThe result
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