The abstract is read at the publisher; the summary is JClub's.
GHB-β-ribose is identified as a biomarker that stays elevated after sodium oxybate dosing for up to 48 hours in blood and 24 hours in urine.
- Why it matters: Forensic detection of GHB is challenging because it clears quickly, is endogenous, and can form after sampling, leaving a narrow analytical window.
- What they did: In a double-blind randomized controlled trial of 30 participants given placebo or a single oral dose of sodium oxybate (50 milligrams per kilogram), untargeted metabolomics was used on blood and urine collected over 5 days.
- The result: Chemical synthesis and liquid chromatography-tandem mass spectrometry confirmed GHB-β-ribose, and its levels were elevated versus placebo and authentic forensic cases, supporting prolonged detection of GHB intake.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.