The abstract is read at the publisher; the summary is JClub's.
ABI1 and ABI2 phosphatases dephosphorylate NRAMP1 at Thr498 and Ser20, coupling ABA signaling to manganese homeostasis and fine-tuning uptake versus endocytosis.
- Why it matters: Mn homeostasis depends on NRAMP1, but the phosphatases that remove its phosphorylation were unknown, leaving a gap in how ABA signaling regulates Mn balance.
- What they did: The study identifies ABI1/ABI2 as NRAMP1 phosphatases and shows Mn stress triggers ABA to inhibit ABI1/2, followed by feedback-driven short-term ABI1/2 reactivation for site-specific dephosphorylation.
- The result: Dephosphorylation at Thr498 and Ser20 restrains NRAMP1 overactivation, helps maintain Mn ion balance, and suggests ABI1/2 attenuation may support long-term adaptation to Mn stress.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.