Wound atlas of Atlantic salmon skin.

A first single-nucleus atlas of healing Atlantic salmon skin profiles 29,706 nuclei across uninjured, 2 dpw, and 14 dpw wounds, resolving 44 transcriptionally distinct cell clusters.

• Why it matters: Wound healing requires coordinated cellular programs to restore tissue integrity, yet scarless repair in non-model vertebrates like Salmo salar remains poorly mapped in space and time.
• What they did: The study generated single-nucleus RNA-seq from wound healing timepoints, then integrated the results with previously published spatial transcriptomics to localize cell populations in the wound microenvironment.
• The result: Spatial-temporal associations were identified for erythrocytes, thrombocytes, macrophages, differentiating muscle cells, fibroblasts, and tenocytes, and transcriptomic plus histological data support a role for the myosepta in coordinating wound and muscle repair.

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