The abstract is read at the publisher; the summary is JClub's.
In adults with persistent post-traumatic headache after mild traumatic brain injury, adrenomedullin infusions induced migraine-like headache in 81% versus 19% with placebo.
- Why it matters: Migraine and persistent post-traumatic headache share clinical features, but whether adrenomedullin-linked signalling contributes to migraine-like headache in this condition is unclear.
- What they did: In a single-centre randomized double-blind placebo-controlled two-way crossover study, 21 adults received 20-minute intravenous adrenomedullin (19.9 pmol kg⁻¹ min⁻¹) or isotonic saline, with headache outcomes tracked for 12 hours.
- The result: Migraine-like headache occurred in 17/21 after adrenomedullin and 4/21 after placebo (paired absolute risk difference 61.9 percentage points; 95% CI 29.7–80.6; one-sided P < 0.001; two-sided P = 0.001), with higher headache-intensity AUC after adrenomedullin.
The findingWhy it mattersWhat they didThe result
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