One battle after another: orthoflavivirus receptors start to be revealed.

Functional entry receptors for yellow fever virus and tick-borne encephalitis virus have been identified as members of the low-density lipoprotein receptor family, reshaping orthoflavivirus entry models.

• Why it matters: Orthoflaviviruses like dengue, Zika, yellow fever, Japanese encephalitis, and West Nile viruses keep emerging and re-emerging, and improved infection biology is needed to enable countermeasures.
• What they did: This review synthesizes recent receptor discoveries and prior receptor knowledge, and proposes a testable framework for orthoflavivirus–host receptor evolution to support prediction tools for receptor usage.
• The result: By linking receptor identification to evolutionary implications, the work suggests it can accelerate antiviral drug and vaccine development and guide experimental testing and computational prediction.

AI summary of the abstract · may contain errors · not medical advice · read the paper.