Tissue-to-bytes: A digital twin for single-cell omics data integration across BRAIN Initiative Cell Atlas Network.

NIMP, a consortium web platform for BICAN, managed 762 human donors, 8,449 brain slabs, and 21,781 sequencing libraries across 11 labs, enabling >18 million single cells.

• Why it matters: BICAN must coordinate limited human brain tissue, enforce standardized metadata, and transparently track how tissue becomes sequencing data across distributed centers.
• What they did: The Neuroanatomy-Anchored Information Management Platform coordinates donor registration, anatomical annotation, tissue allocation, sequencing workflows, QC/QA, and archive deposition with end-to-end provenance.
• The result: After 3 years of production deployment, NIMP supports FAIR, provenance-aware resource management and provides a reusable system for future large-scale atlas and multi-network coordination.

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