The abstract is read at the publisher; the summary is JClub's.
Early oral nutritional supplementation at CCRT start in stage II–IVA nasopharyngeal carcinoma patients reduced >5% weight loss by completion (65.4% vs 80.7%; RR 0.81).
- Why it matters: Optimal timing of oral nutritional supplementation during concurrent chemoradiotherapy for nasopharyngeal carcinoma is uncertain, including whether earlier use improves outcomes and is cost-effective.
- What they did: In a multicenter open-label randomized trial (6 Chinese tertiary hospitals; July 2021–May 2025), 216 patients with PG-SGA 0–8 were assigned 1:1 to early ONS or routine ONS after nutritional decline.
- The result: Early ONS also lowered grade 3+ radiation-induced oral mucositis (14.0% vs 26.6%; RR 0.53) and showed a slightly lower best-case cost ($9560.56 vs $9685.23) with similar short-term QALYs.
The findingWhy it mattersWhat they didThe result
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