Treatment of Acute Ischemic Stroke: A Review.

Intravenous thrombolysis for acute ischemic stroke within 4.5 hours in patients with disabling symptoms is linked to an approximately 10% absolute increase in better functional outcomes.

• Why it matters: Acute ischemic stroke is a leading cause of disability and death, and timely treatment is needed to restore blood flow and limit neurologic injury.
• What they did: Patients with suspected stroke should undergo urgent brain imaging, typically noncontrast CT, and receive first-line intravenous thrombolysis (tenecteplase or alteplase) per 2026 AHA/ASA guidance when no intracranial hemorrhage or thrombolysis contraindications are present.
• The result: Pooled randomized trial data indicate about a 10% absolute improvement in the probability of better functional outcome, supporting thrombolysis as a key early therapy.

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