The abstract is read at the publisher; the summary is JClub's.
In a prospective cohort of 27 bvFTD patients versus 25 bvFTD false-positives, patient–clinician insight discrepancy discriminated groups with AUC 0.99 (95% CI 0.97–1.00).
- Why it matters: Behavioural symptoms can mimic bvFTD in psychiatric phenocopies, creating diagnostic uncertainty. Quantifying insight aims to separate neurodegeneration from psychiatric presentations.
- What they did: Participants completed modified Frontal Behavioural Inventory symptom ratings from patients, informants, and clinicians; discrepancy scores were tested with leave-one-out cross-validation AUC. Neuroimaging assessed network-level associations of insight in bvFTD.
- The result: bvFTD patients under-endorsed symptoms versus clinicians (FBI 6.62 ± 8.80 vs 27.67 ± 8.35, P < 0.001), while informant ratings did not differ (P = 0.14). Reduced insight in bvFTD was linked to salience and semantic appraisal network degeneration, and patient–informant discrepancy showed fair discrimination (AUC 0.71).
The findingWhy it mattersWhat they didThe result
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