Preventing Malaria Infections and Moving toward Malaria Elimination.

Next-generation malaria prevention is being reshaped by expanded seasonal malaria chemoprevention and RTS,S/AS01 and R21/Matrix-M vaccines, amid 282 million cases and 610,000 deaths in 2024.

• Why it matters: Progress has stalled, yet malaria remains a major global health burden, especially for African children, creating urgency for updated strategies toward elimination.
• What they did: This review synthesizes current and emerging approaches—vector control, transmission-blocking interventions, chemoprevention, monoclonal antibodies, and vaccines—highlighting next-generation nets and surveillance-driven deployment.
• The result: It suggests that long-acting injectable chemoprevention, transmission-blocking medicines and vaccines, and improved surveillance could accelerate progress, but success will require locally tailored integrated combinations and strong national capacity.

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