The abstract is read at the publisher; the summary is JClub's.
A Pt-N-C-NH3 single-atom nanozyme reprograms uric acid oxidation from a two-electron to a four-electron pathway, enabling stable microneedle chemiluminescent sensing.
- Why it matters: Conventional H2O2-based UA assays are unstable and suffer interference from reductive species, limiting reliable biomarker detection in complex samples.
- What they did: They engineered Pt-N-C-NH3 by decreasing graphitic nitrogen to tune the Pt electronic microenvironment, lowering the rate-determining absorbed oxygen-to-absorbed hydroxyl free-energy change from 1.25 to 0.62 eV.
- The result: In a microneedle platform, UA detection spans 50.00–1000.00 μM with a 15.86 μM limit and retains 97.57% signal stability against reductive interferents.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.