The abstract is read at the publisher; the summary is JClub's.
Electromechanically driven plasmonic nano-oscillators enable charge-resolved, label-free multiplex sensing across a ∼300-fold molecular weight range in a single field of view.
- Why it matters: Label-free multiplex diagnostics are hard because sensor signals often scale with analyte mass, limiting sensitivity for low-molecular-weight targets.
- What they did: Size-encoded nanoparticles tethered to a plasmonic surface are electrically actuated to oscillate vertically in the evanescent field, while distance-resolved surface plasmon resonance imaging tracks motion. Binding changes effective surface charge, altering electrostatic-driven forces and oscillation amplitude to transduce charge-to-motion.
- The result: The approach quantifies microRNAs, proteins, and small molecules and profiles tumor-associated microRNAs in pretreated supernatants from patient-derived breast cancer cells across 24 clinical samples.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.