The abstract is read at the publisher; the summary is JClub's.
Imaging-derived white matter free water (FW-WM) is strongly linked to stroke (OR = 3.14) and dementia (OR = 4.15) in UK Biobank and ADNI participants.
- Why it matters: The genetic basis and clinical relevance of tract-specific FW-WM, an extracellular water and microstructure marker from diffusion MRI, are not well established.
- What they did: Multi-omics analyses across 42,039 individuals combined diffusion MRI tract measures with genome-wide association, proteomics, and bidirectional Mendelian randomization, identifying 27 independent loci and 88 prioritized genes.
- The result: Genetically predicted higher FW-WM and baseline FW-WM predicted MCI-to-AD progression (HR = 2.58), with hypertension linked to FW-WM and both associated with higher stroke and cognitive impairment risk.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.