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Intraspecies competition reveals branched-chain amino acid homeostasis as a targetable metabolic vulnerability in uropathogenic E. coli.
mBio · · Journal Article
George, Vanitshavit + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Branched-chain amino acid homeostasis is a targetable metabolic vulnerability in uropathogenic Escherichia coli, with ABU 83972 fitness dropping dose-dependently when leucine and isoleucine are added.
- Why it matters: Understanding how a urinary probiotic Escherichia coli outcompetes uropathogens in the bladder could reveal actionable nutritional bottlenecks for UTI control.
- What they did: The authors used comparative metabolomics and intraspecies competition assays in human urine, then tested metabolite supplementation, BrnQ function, amino-acid measurements, chemical inhibition of BCAA biosynthesis, and mouse UTI models.
- The result: ABU 83972’s fitness advantage over UPEC CFT073 is linked to BrnQ, and disrupting BCAA import or biosynthesis suggests a chemical-inhibitor strategy to limit UPEC growth during UTI.
The findingWhy it mattersWhat they didThe result
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