Nat GenetJClub
A multi-tissue atlas of genetic regulatory effects in sheep.
Nature Genetics · · Journal Article · Open access
Gong, Zhuang + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
SheepGTEx in a multibreed cohort links regulatory variants to molecular phenotypes across 51 tissues, fine-mapping 322,468 primary and 114,017 nonprimary effects from 6,761 RNA-seq samples.
- Why it matters: Understanding how genetic variants shape genome function in livestock is needed for precision agriculture and for comparing regulatory biology across mammals.
- What they did: In the FarmGTEx pilot, the SheepGTEx resource analyzed 6,761 RNA sequencing samples spanning 51 primary tissues to map and fine-map regulatory effects.
- The result: The atlas reveals extensive allelic heterogeneity and pleiotropy, and it enables discovery of regulatory mechanisms for 34 complex traits, divergence between European and Asian breeds, and adaptive evolution over the past 10 millennia.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.
- Open access
- 11 cites