Nat Rev MicrobiolJClub
The mammalian archaeome: diversity, function and emerging roles in health and disease.
Nature Reviews Microbiology · · Review
Kumpitsch, Bauer + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Archaea, especially methanogenic archaea and Methanobrevibacter spp., are widespread colonizers of mammalian hosts, with key roles in gut metabolism and host interaction.
- Why it matters: Their contribution to mammalian microbiome function has been historically overlooked, and external factors like diet, age, and health status may shape archaeal ecology and disease links.
- What they did: This Review synthesizes evidence on the distribution, diversity, and functions of the mammalian archaeome, emphasizing humans and ruminants and focusing on archaeal–bacterial–host interactions.
- The result: The work supports translational directions, including methane mitigation strategies in cattle and emerging associations between the archaeome and human disease, arguing archaeome understanding is essential for microbiome biology.
The findingWhy it mattersWhat they didThe result
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