The abstract is read at the publisher; the summary is JClub's.
Allelic homogenization of detoxification genes RsCYP3A24 and RsGSTF5 in Rhizoctonia solani is associated with metabolic resistance to SYP-14288 under fungicide selection pressure.
- Why it matters: Fungicide resistance in multinucleate fungi limits disease control, but how allelic variation and nuclear heterogeneity shape metabolic detoxification is unclear.
- What they did: The study genotyped parental and resistant mutants, tracked nuclear heterogeneity during continuous subculturing, and used transcriptomic/genomic profiling plus enzymatic assays and heterologous expression in Escherichia coli.
- The result: Resistant mutants showed reduced heterogeneity with apparent allelic fixation, coordinately upregulated and optimized detoxification gene composition, and greater SYP-14288 detoxification efficiency linked to fixed resistance-associated alleles.
The findingWhy it mattersWhat they didThe result
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