Cell RepJClub
Single-cell and spatial characterization of the human pancreas in cystic fibrosis.
Cell Reports · · Journal Article · Open access
Mummey, Corban + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Single-cell and spatial profiling of 2.04 M cells from 23 human pancreas donors shows CF-linked beta cell dysfunction, with reduced beta cells near adipose and collagen.
- Why it matters: CF damages pancreatic structure and contributes to CFRD, but the cellular microenvironmental drivers of beta cell failure are unclear.
- What they did: The study profiled 2.04 M cells using single-cell and spatial approaches across 23 non-disease or CF pancreas donors, mapping ductal, immune, fibrotic, and islet niches.
- The result: CF shows altered high-mucin ductal localization, immune–pro-fibrotic crosstalk, and extensive beta cell stress with compensatory secretion signals, suggesting niche-specific targets to preserve beta cells in CFRD.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.
- Open access
- 2 cites