The abstract is read at the publisher; the summary is JClub's.
Decidua-enriched effector-like memory CD8+ T cells marked by CD45RA in humans and CX3CR1 in mice accumulate in the maternal-fetal interface via CX3CL1.
- Why it matters: Immune privilege at the maternal-fetal interface must balance antimicrobial defense with fetal tolerance, but how CD8+ T cells localize there is unclear.
- What they did: The study identified CD45RA+ (human) and CX3CR1+ (mouse) decidual memory CD8+ T cells, then tested recruitment by disrupting Cx3cr1 or uterine Cx3cl1 and comparing transcriptional and functional profiles.
- The result: CX3CL1-driven accumulation enhanced local control of prenatal Listeria monocytogenes and reduced infection-associated fetal loss, while fetal antigen-specific CD8+ T cell accumulation and fetal resorption were independent of uterine CX3CL1.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.