The abstract is read at the publisher; the summary is JClub's.
Pathogen-induced phosphorylation of potato TF StbZIP18 at threonine 337 converts its nuclear condensates into numerous smaller, dynamic transcriptional hubs that enhance immune responses.
- Why it matters: Phosphorylation is known to regulate transcription factors, but how it reorganizes condensates and changes transcriptional output during plant immunity was unclear.
- What they did: After infection by Phytophthora infestans, StMPK9 phosphorylates StbZIP18 at threonine 337; phospho-null StbZIP18T337A and phospho-mimetic StbZIP18T337E were compared, and TurboID mapped interactions with StMBF1c.
- The result: StbZIP18T337A keeps StbZIP18 in low-activity condensates and compromises immunity, while StbZIP18T337E constitutively forms active condensates, drives defense gene expression including StMYB44, and enables StbZIP18–StMBF1c activation hubs.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.