Intermittent fasting enhances muscle regeneration via an EDA2R-NIK-myomixer axis.

Intermittent fasting in mice upregulates a myogenic program, including Myomixer, and enhances regeneration of injured skeletal muscle by expanding satellite cells and boosting progenitor fusion.

• Why it matters: Energy availability can shape myogenesis, but how intermittent fasting affects satellite-cell–driven muscle repair was unclear.
• What they did: Mice underwent intermittent fasting, and injured-muscle regeneration was assessed alongside satellite-cell abundance and progenitor proliferation/fusion; SC-depletion abolished these benefits, while EDA2R-NIK signaling increased Myomixer expression and fusion in myoblasts.
• The result: EDA2R or NIK loss prevented intermittent-fasting–driven myogenic effects, and Duchenne muscular dystrophy mice also appeared to benefit, suggesting an EDA2R-NIK–Myomixer axis for recovery after muscle damage.

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