The abstract is read at the publisher; the summary is JClub's.
Early achievement of complete biochemical remission within 6 months in ectopic Cushing syndrome is linked to lower late complications and Cushing syndrome-related mortality, with adjusted HRs 0·55 and 0·49.
- Why it matters: Ectopic Cushing syndrome is rare and has limited outcome data, leaving uncertainty about its clinical course and which factors predict complications and death.
- What they did: In an international retrospective cohort of 1463 consecutively identified patients from 49 high-volume endocrine referral centres, investigators assessed presentation, management, complications, and mortality, stratifying outcomes by remission status and timing using landmark methods.
- The result: Cushing syndrome-related mortality was 13·4% (196/1463), with 42·8% (626/1463) dying overall; infections (31·7%) were most common, and remission within 6 months predicted fewer late complications and lower Cushing syndrome-related mortality.
The findingWhy it mattersWhat they didThe result
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