Catalytic asymmetric dearomatization of (hetero)aromatic frameworks.

Nature Communications · 6 Oct 2026 · Journal Article · Open access

Chang, Li + more

The abstract is read at the publisher; the summary is JClub's.

Mechanism-guided asymmetric dearomative cycloaddition using vinylidene ortho-quinone methides achieves excellent regio-, chemo-, and enantioselectivity at challenging sites on (hetero)polycyclic aromatics.

Why it matters: Selectivity control in asymmetric dearomative cycloadditions is difficult, limiting reliable synthesis of chiral polycyclic frameworks from diverse aromatic substrates.
What they did: Density functional theory showed the synthons’ charge distribution, orbital delocalization, and narrow frontier molecular orbital gap enable multisite reactivity with predictable selectivity.
The result: Cycloadditions were demonstrated with excellent selectivity at the C6a-C13c site of dibenzo[c,g]carbazole, the C9-C10 site of anthracene, and the C5-C6/C5-C8 sites of quinoline, enabling modular access to chiral polycyclic scaffolds.

AI summary of the abstract · may contain errors · not medical advice · read the paper.

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De novo design of enantioselective artificial metalloenzyme photocatalysts.
Nature · 21 Oct 2026 · Journal Article
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Generative protein design plus directed evolution created de novo artificial metalloenzyme scaffolds that enable highly enantioselective photocatalysis with metal polypyridine photocatalysts.
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Enhancing ω-transaminase catalysis of bulky substrates guided by binding mechanism.
Nature Communications · 14 Oct 2026 · Journal Article
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P450-catalyzed enantiodivergent kinetic oxidation to access chiral haloalcohols.
Nature Communications · 9 Oct 2026 · Journal Article
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Catalytic asymmetric dearomatization of (hetero)aromatic frameworks.

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De novo design of enantioselective artificial metalloenzyme photocatalysts.

Enhancing ω-transaminase catalysis of bulky substrates guided by binding mechanism.

P450-catalyzed enantiodivergent kinetic oxidation to access chiral haloalcohols.

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