RNAactDrug 2.0: an updated resource for systematically exploring molecular features associated with drug sensitivity across multi-omics datasets.

RNAactDrug 2.0 integrates ~30 000 drugs with 38 908 RNA molecules and 22 800 375 drug–RNA associations across expression, CNV, mutation, and methylation layers.

• Why it matters: Drug sensitivity biomarkers remain hard to identify consistently across heterogeneous multi-omics data, limiting systematic discovery and clinical translation.
• What they did: The updated database compiles 11 099 TCGA cases across 33 cancer types and ~3.8 million single cells from >200 datasets, plus 26 440 enhancers with 788 444 drug–enhancer links.
• The result: It enables clinical, pan-cancer, and cell type–specific analyses of drug sensitivity–associated RNA and regulatory features, supporting biomarker discovery and personalized therapy research.

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