Nucleic Acids ResJClub
The TCR Motif Atlas: a database of specificities for TCRs recognizing viral, cancer, and autoimmune epitopes.
Nucleic Acids Research · · Journal Article
Tadros, Shah + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
The TCR Motif Atlas database visualizes TCR-epitope recognition specificity for hundreds of epitopes, highlighting V and J genes, CDR3 lengths, and enriched amino acids.
- Why it matters: Many machine learning models for TCR-epitope specificity are hard to interpret, leaving users without clear, visual insight into what sequence features drive recognition.
- What they did: The atlas uses the probabilistic framework of TCR specificity profiles (TSPs) to compare epitope-specific TCRs against baseline repertoires, and it supports interactive TSP building from user-provided TCR sequences.
- The result: Users can investigate epitope recognition specificity and explore repertoire biases, with links to curated epitope-specific TCR compilations and crystal structures of TCR-epitope complexes.
The findingWhy it mattersWhat they didThe result
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