InterPro: the protein sequence classification resource in 2027.

InterPro version 110.0 expands protein sequence classification coverage, with InterPro-N deep learning raising UniProtKB sequence coverage to over 90%.

• Why it matters: Protein function annotation depends on integrating diverse evidence, and researchers need up-to-date, accessible tools that scale to very large sequence repositories.
• What they did: The team reports InterPro 110.0 status, including new signatures, the re-engineered InterProScan 6, structure-based domain classification plus AlphaFold predicted structures, and a redesigned viewer.
• The result: InterPro has added 9484 new entries over two years to reach 54 922 total, and it enables programmatic querying via a new Model Context Protocol (MCP) server for AI assistants.

AI summary of the abstract · may contain errors · not medical advice · read the paper.